Sensitive detection of SARS-CoV-2 molecular markers in urban community sewersheds using automated viral RNA purification and digital droplet PCRArticle Published on 2022-11-152022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] affecting approach automated Care Community correlation COVID-19 COVID-19 case detection of marker Detroit disadvantage Effectiveness Epidemiology faster Final handling Health identify inhibitor Local marker molecular number of sample outbreak PCR PerkinElmer Prevent Promega public health authority purification required RNA RNA purification SARS-CoV-2 sensitive sensitivity Standard state the SARS-CoV-2 virus Thermofisher time-consuming Viral RNA Volume wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2022.157547 PMC 바로가기
In silico analysis of SARS-CoV-2 spike protein N501Y and N501T mutation effects on human ACE2 bindingSARS-CoV-2 스파이크 단백질 N501Y 및 N501T 돌연변이가 인간 ACE2 결합에 미치는 영향에 대한 실리코 분석Article Published on 2022-11-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis analyzed anti-SARS-CoV-2 antibodies Anti-viral drugs antisense attachment binding binding energy binding free energy classic Dynamics Effect Effect of mutations on binding energy effective free energy hACE2 hACE2 receptor hACE2-SARS-CoV-2 spike protein binding. handling highlight Host human ACE2 maintain molecular molecular dynamics molecular dynamics simulations Mutation N501Y N501Y and N501T mutations nine outcome predicted Protein binding raised Replication SARS CoV SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 spike protein Spike protein survival Transmissibility treatment strategy Vaccines virus [DOI] 10.1016/j.jmgm.2022.108260 PMC 바로가기 [Article Type] Article
Diffusion-Induced Ingress of Angiotensin-Converting Enzyme 2 into the Charge Conducting Path of a Pentacene Channel for Efficient Detection of SARS-CoV-2 in Saliva SamplesArticle Published on 2022-10-282022-11-15 Journal: ACS Sensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] accelerate ACE2 angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) biosensor can be used channel charge Conducting correlation COVID-19 detection diagnostic test disease efficient false-negative field-effect transistor. gold standard growth handling highest integration Laboratory Large-scale testing less medium molecular Organic field-effect transistor path pathogen platform POC point-of-care Rapid receptor remote monitoring reported Saliva Sample SARS-CoV-2 sensitivity specimens Spread statistical analysis the disease the epidemic the SARS-CoV-2 virus the spike protein transfer Viral RNA viral titer virus [DOI] 10.1021/acssensors.2c01287 PMC 바로가기
In vitro testing of salt coating of fabrics as a potential antiviral agent in reusable face masksArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] added airway Antiviral cloth mask cloth masks collected conditions coronavirus disease COVID-19 cultures dependent on dilutions distribution Effectiveness eight epithelia epithelial evaluated Face mask Face masks H3N2 handling incubated mandatory Masks pandemic protocol quantified reduced relative remained risk Sodium chloride tested turn viral replication virus particle virus replication wearing face mask [DOI] 10.1038/s41598-022-21442-7 PMC 바로가기
Twitter sentiment analysis: An Arabic text mining approach based on COVID-19Article Published on 2022-10-102022-11-16 Journal: Frontiers in Public Health [Category] 치료기술, [키워드] Analysis approach Arabic changed country COVID-19 COVID-19 pandemic Culture dataset effort Express Facebook Government Gulf handling information Instagram Interaction machine learning machine learning - ML media mitigate natural language processing platform problem public health raw data reporter Research sentiment analysis (SA). social media social media platform social media platforms Spread spread of COVID-19 synthetic Synthetic Minority Over-sampling Technique (SMOTE) technique text text mining transmitted virus was done YouTube [DOI] 10.3389/fpubh.2022.966779 PMC 바로가기
Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart TissuesArticle Published on 2022-10-012022-11-15 Journal: Advanced Science [Category] 신약개발, 치료제, [키워드] antiviral drugs approved drugs ATP2A2 cardiotoxic effect Cardiotoxicity cell death Clinical data clinical trial clinically concentrations contractile Coronavirus disease 2019 COVID-19 demonstrated drug drug candidate drug treatments dysregulation effective engineered heart tissue evaluate expression of gene fumarate handling HCN4 heart heart tissue High Throughput Screening Human human pluripotent stem cell-derived cardiomyocytes induced ion homeostasis limit MYH6 Patient powerful tool regulate Remdesivir Repurposed drug repurposed drugs for COVID-19. reveal Ritonavir RNA-seq analysis significantly Spread STEM therapy TNNT2 [DOI] 10.1002/advs.202203388 PMC 바로가기
Toward a big picture of COVID-19Article Published on 2022-10-012022-11-15 Journal: Pharmacology Research & Perspectives [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition available data benefit caused chronic inflammation clinical trial Corona COVID-19 Critical Culture cybernetics driven by drug eco ecosystem effort ENhance Epidemiology Evidence executive explain explicit Governance handling Inflammation knowledge Laboratory limitation Local lockdown management media mutant National occurred organization pandemic Pandemics pathology Perspective problem reflect Regulation Research SARS-CoV2 suggested System Treatment zoonoses zoonosis zoonosis. [DOI] 10.1002/prp2.996 PMC 바로가기
Pre-analytical sample stabilization by different sampling devices for PCR-based COVID-19 diagnosticsPCR 기반 COVID-19 진단을 위한 다양한 샘플링 장치에 의한 사전 분석 샘플 안정화Article Published on 2022-09-252022-09-11 Journal: New biotechnology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Bacterial cell culture systems copy number copy numbers COVID-19 Critical detectability detectable diagnostic diagnostic testing diagnostics examined except for gold gold standard growth handling healthcare worker infectious Infectivity inhibited outbreak pandemic Patient Pre-analytic Quantitative RT-PCR reduction remained RNA RNA stability room temperature Saliva Saliva collection devices SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 RNA Sensitivity and specificity specimen specimen collection stability Swab Swab systems. temperature test results tested the SARS-CoV-2 Transport Viral Viral RNA [DOI] 10.1016/j.nbt.2022.04.001 PMC 바로가기 [Article Type] Article
First reported nosocomial SARS-CoV-2 outbreak in a hospital-based laundry facility병원 기반 세탁 시설에서 처음 보고된 병원 SARS-CoV-2 발생Original Paper Published on 2022-09-152022-09-11 Journal: Epidemiology and Infection [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition assumed Cluster Contamination coronavirus COVID-19 defined detect Drinking Epidemiological investigation Genetic handling Health care Health care worker health care workers help identify index case index cases Infection laundromat facility less molecular Next-generation sequencing nosocomial observation observations outbreak PCR tests Phylogenetic analysis PPE qRT-PCR Questionnaires reported respiratory SARS-CoV-2 SARS-CoV-2 transmission screened sequenced swabs Transmission Viral Viral RNA was performed [DOI] 10.1017/S0950268821002016 PMC 바로가기 [Article Type] Original Paper
SARS-CoV-2 Production, Purification Methods and UV Inactivation for Proteomics and Structural StudiesArticle Published on 2022-09-082022-11-16 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome biosafety can be used cell activation conditions core Coronavirus-2 COVID-19 died downstream effective experiments faster handling inactivated inactivation Laboratory Microscopy pandemic pathogenicity Production purification resulting SARS-CoV-2 Sequencing Seven significantly size exclusion structural studies. sucrose cushion ultracentrifugation UV inactivation virus [DOI] 10.3390/v14091989 PMC 바로가기